Decisions spared

Social science, spared again.

www.sciencemag.org SCIENCE VOL 333 5 AUGUST 2011 663 COVER A pair of chemical compounds (light blue and purple) target wild-type and mutant forms of the Plasmodium falciparum chloroquine resistance transporter, which mediates the parasite’s (yellow) resistance to the widely used antimalarial drug. Using high-throughput chemical and genetic analyses, Yuan et al. identify potential new antimalari...

The Varus Knee Reveals Differential Expression Patterns of miRNAs in Spared vs. Non-spared Compartments

Introduction MicroRNAs (miRNAs) function by repressing cellular protein levels to provide a sophisticated level of gene regulation that coordinates a broad spectrum of biological processes. MiRNA inhibition of mRNA translation has emerged as an important regulator of chondrogenic and osteogenic development, osteoblast, osteoclast and chondrocyte cell growth and differentiation, and tissue homeo...

Agricultural intensification: will land spared from farming be land spared for nature?

How can intensive agricultural systems be designed so that they have fewer and smaller impacts on surrounding ecosystems? This is not a new challenge, but its importance to conservation—particularly in developing regions—has become apparent in recent years. This challenge is a major part of the ongoing effort to provide for the needs of a growing human population and at the same time sustain th...

Decisions, decisions

Journals are exploring new approaches to peer review in order to reduce bias, increase transparency and respond to author preferences. Funders are also getting involved.

Decisions, decisions